The phantom menace of gene patents
Gaisser, Sibylle; Hopkins, Michael M; Liddell, Kathleen; Zika, Eleni; Ibarreta, Dolores (2009)
Gaisser, Sibylle; Hopkins, Michael M; Liddell, Kathleen; Zika, Eleni...
Nature 26, 458 (7237), S. 407-408.
DOI: 10.1038/458407a
Pharmacogenetics in Europe: barriers and opportunities
Gurwitz, David; Zika, Eleni; Hopkins, Michael M; Gaisser, Sibylle; Ibarreta, Dolores (2009)
Gurwitz, David; Zika, Eleni; Hopkins, Michael M; Gaisser, Sibylle...
Public Health Genomics 12 (3), S. 134-144.
DOI: 10.1159/000189625
Open Access
This paper reviews the current situation in the field of pharmacogenetics/pharmacogenomics (PGx) in Europe. High expectations surrounding the clinical application of PGx remain largely unmet, as only a limited number of such applications have actually reached the market and clinical practice. Thus, the potential impact of PGx-based diagnostics on healthcare and its socio-economic implications are still unclear. With the aim of shedding some light on these uncertainties, the Institute for Prospective Technological Studies (IPTS) of the European Commission’s Joint Research Centre (JRC) has conducted a review of the ‘state of the art’ and a further analysis on the use of pharmacogenetics diagnostics for preventing toxic drug reactions and improving drug efficacy in Europe. The paper presents highlights from the JRC-IPTS studies and discusses possibilities for improving translation of PGx research in Europe by comparing some experiences in the USA. We also illustrate the related barriers for the clinical uptake of PGx in Europe with specific case-studies. Most of the barriers identified extend beyond the European context. This reflects the global problems of scarcity of data demonstrating proven clinical validity or utility and favorable cost-effectiveness studies to support the clinical application of PGx diagnostic tests in the clinical setting. Another key barrier is the lack of incentives for the private sector to invest in the development and licensing of PGx diagnostic tests for improving the safety and efficacy of out-of-patent drugs. It therefore seems that one key aspect where policy can affect the clinical uptake of PGx is via sustaining large-scale industry-academia collaborations for developing and proving the utility of PGx diagnostics.
EU policies in personalized medicine-related technologies
Gaisser, Sibylle; Vignola-Gagné, Etienne; Hüsing, Bärbel; Enzing, Christien; van der Valk, Tessa (2009)
Gaisser, Sibylle; Vignola-Gagné, Etienne; Hüsing, Bärbel; Enzing, Christien...
6 (1).
DOI: 10.2217/17410541.6.1.93
Against the background of a number of first drug–diagnostic co-products developed and introduced into the European market, European decision-makers feel impelled to react and position themselves in the field of personalized medicine. Their reactions cover a broad range, from the analysis of knowledge requirements for market approval to the need for translational activities and the possible contribution of pharmacogenetics to public health. This article summarizes the current positions of European institutions, based on literature review and expert consultation for three items associated with personalized medicine: biobanks, genetic diagnostics and drug–diagnostic co-products, and provides an outlook on requirements for an effective future European policy on personalized medicine
Shared memory parallelization of the pe physics engine, Bachelor thesis
Geißelsöder, Stefan (2008)
Untersuchung zum Impactverhalten von Elastomeren mit Hilfe eines Hochgeschwindigkeits-Prüfstandes
Sover, Alexandru; Frormann, Lars; Kipscholl, R. (2008)
26. Vortrags-und Diskussionsveranstaltung, Werkstoffprüfung 2008, Deutschen Verband für Materialforschung und –prüfung e.V., Dezember 2008.
Untersuchungen zum Impactverhalten von Elastomeren mit Hilfe eines Hoch- geschwindigkeits-Prüfstandes,
Sover, Alexandru; Frormann, Lars (2008)
Abschlussbericht, Arbeitsgemeinschaft industrieller Forschungseinrichtungen „Otto von Guerick“ e.V. (AiF), (KF0188703VT6).
Untersuchung des Durchstoßverhaltens von Elastomeren mittels neuartigem Hochgeschwindigkeits-Prüfstand
Sover, Alexandru; Frormann, Lars (2008)
13. Internationale Fachtagung Polymerwerkstoffe 2008, Halle/Saale, September 2008.
Untersuchungen zum Impactverhalten von Elastomeren mit Hilfe eines Hochgeschwindigkeits-Prüfstandes
Sover, Alexandru (2008)
Steinbeis-Tag 2008, Stuttgart .
Interaktion am traditionellen Instrument
Pöpel, Cornelius (2008)
Workshop Proceedings der Tagungen Mensch & Computer 2008, DeLFI 2008 und Cognitive Design 2008. Lübeck, 07.-10.09.2008. Berlin: Logos Verlag, S. 116-119.
Towards Participatory Design and Evaluation of Theremin-based Musical Interfaces
Geiger, Christian; Reckter, Holger; Paschke, David; Schulz, Florian; Pöpel, Cornelius (2008)
Geiger, Christian; Reckter, Holger; Paschke, David; Schulz, Florian...
Proceedings of the 2008 Conference on New Interfaces for Musical Expression (NIME08). Genova, Italy, 04.-08.06.2008, S. 303-306.
Die Fallstudie aus der Wirtschaftsinformatik: Aufbau einer Kundensupportlösung nach ITIL
Knüpffer, Wolf (2008)
WISU - Das Wirtschaftsstudium 02/2008, S. 240-242.
Corporate Governance am Beispiel der DAX30-Unternehmen
Müller, Jochem; Le, Tan Thanh (2008)
Lohmar: Josef Eul Verlag (Controlling Forum - Wege zum Erfolg, Bd. 6).
Smart Shopping im Einzelhandel. Wissenschaftliche Studie über die Ursachen dieses Kaufverhaltens und mögliche Abwehrstrategien
Müller, Jochem; Stein, Christian (2008)
Lohmar: Josef Eul Verlag (Marketing-Praxis, Bd. 2).
Driving Sound Synthesis with a Live Audio Signal
Pöpel, Cornelius (2008)
Interactive Multimedia Music Technologies. Hershey, Pa: IGI Global, S. 167-194.
Formalized and Non-formalized Expression in Musical Interfaces
Pöpel, Cornelius (2008)
Transdisciplinary Digital Art. Sound, Vision and the New Screen. Communications in Computer and Information Science, vol 7. Springer, Berlin, Heidelberg, S. 358-373.
DOI: 10.1007/978-3-540-79486-8_29
Biophotonik in Deutschland: Trends und Perspektiven
Jürgens, Marion; Popp, Jürgen (2008)
BioPhotonik 2008, S. 22-26.
Untersuchungen zur Entwicklung und Herstellung eines neuartigen Schleif- und Polierverfahrens mittels Dosierung über Hohlfasern bzw. hohle Monofilamente,
Sover, Alexandru; Frormann, Lars (2007)
Abschlussbericht, Arbeitsgemeinschaft industrieller Forschungseinrichtungen „Otto von Guerick“ e.V. (AiF), (KF0188707LK6).
Dehnungsmessstreifen (DMS) aus Basis extrinsisch elektrisch leitfähiger Polymerwerkstoffe zur Ermittlung der Dehnung von Bauteilen bzw. Objekten mittels Widerstandsänderung derartiger DMS bei Verformung (DE 10 2006 027 616 A1)
Frormann, Lars; Sover, Alexandru (2007)
Deutsches Patent- und Markenamt.
Digital Rights Management. Studienblatt zur Wirtschaftsinformatik
Knüpffer, Wolf (2007)
WISU - Das Wirtschaftsstudium 04/2007.
hot_strings SIG
Pöpel, Cornelius; Marx, Günter (2007)
Proceedings of the 7th international conference on New interfaces for musical expression - NIME '07. New York, 06.-10.06.2007. New York: ACM Press, S. 281-284.
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